Conformal Irradiation for Moving Targets in Heavy Ion Radiotherapy with Raster-Scanning Beam Delivery System (Ⅰ) Simulations

LI Qiang

Chinese Physics C> 2005, Vol. 29> Issue(10) : 1006-1011

Conformal Irradiation for Moving Targets in Heavy Ion Radiotherapy with Raster-Scanning Beam Delivery System (Ⅰ) Simulations

LI Qiang ^,

Institute of Modern Physics,Chinese Academy of Sciences,Lanzhou 730000,China2 German Heavy-Ion Research Center GSI,Darmstadt 64291,Germany

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Abstract：
Within the framework of the pilot heavy-ion therapy facility at GSI equipping an active beam delivery system of advanced raster scanning technique, the investigation of actively conformal irradiation to moving tumors using heavy ions is underway. The influences of target motion on dose homogeneity and conformity degree were theoretically studied under the condition of the active raster-scanning beam delivery system.The relationship between the target motion with different patterns and the uniformities of doses delivered by the raster scanner to different iso-energy slices of the moving target were simulated with an experimentally measured beam spill. Several strategies improving the dose homogeneity in the moving target volume were derived from these simulation results. The simulations presented in this paper provide an effective means for evaluating the dose distribution for a moving target, and the results and implications of this theoretical work establish a substantial basis for feasibility experiments of the compensation for target motion with the active raster scanner at GSI.

References

[1]

. Schulz-Ertner D, Nikoghosyan A, Thilmann C et al. Int. J. Radiat. Oncol. Biol. Phys., 2004, 58: 631—6402. Haken R, Balter J, Marsh L et al. Int. J. Radiat. Oncol. Boil. Phys., 1997, 38: 613—6173. Okumura T, Tsuji H, Tsujii H. Compensation of Target Motion. In: Ion Beams in Tumor Therapy. Linz U Ed. London: Chapman and Hall, 1995, 308—3154. Wong J, Sharpe M, Jaffray D et al. Int. J. Radiat. Oncol. Biol. Phys., 1999, 44: 911—9195. Ohara K, Okumura T, Akisada M et al. Int. J. Radiat. Oncol. Biol. Phys., 1989, 17: 853—8576. Kubo H D, Hill B C. Phys. Med. Boil., 1996, 41: 83—917. Minohara S, Kanai T, Endo M et al. Int. J. Radiat. Oncol. Biol. Phys., 2000, 47: 1097—11038. Haberer T, Becher W, Schardt D et al. Nucl. Instrum. Methods, 1993, A330: 296—3059. Kraft G. Prog. Part. Nucl. Phys., 2000, 45: S473—S54410. Shimizu S, Shirato H, Aoyama H et al. Int. J. Radiat. Oncol. Biol. Phys., 2000, 48: 471—47411. Yu C X, Jaffray D A, Wong J W. Phys. Med. Boil., 1998,43: 91—10412. Kraemer M et al. Phys. Med. Biol., 2000, 45: 329913. Kraemer M, Scholz M. Phys. Med. Biol., 2000, 45: 331914. Schlegel W, Pastyr O, Bortfeld T et al. Int. J. Radiat. Oncol. Biol. Phys., 1992, 24: 781—78715. Brusasco C et al. Nucl. Instrum. Methods, 2000, B168:57816. Li Q et al. Phys. Med. Biol., 2004, 49: 302917. Weber U, Becher W, Kraft G. Phys. Med. Biol., 2000, 45:3627—364118. Phillips M H et al. Phys. Med. Biol., 1992, 37: 22319. Spielberger B et al. Phys. Med. Biol., 2001, 46: 2889

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LI Qiang. Conformal Irradiation for Moving Targets in Heavy Ion Radiotherapy with Raster-Scanning Beam Delivery System (Ⅰ) Simulations[J]. Chinese Physics C, 2005, 29(10): 1006-1011.

LI Qiang. Conformal Irradiation for Moving Targets in Heavy Ion Radiotherapy with Raster-Scanning Beam Delivery System (Ⅰ) Simulations[J]. Chinese Physics C, 2005, 29(10): 1006-1011. shu

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Received: 2005-01-11
Revised: 1900-01-01

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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

Conformal Irradiation for Moving Targets in Heavy Ion Radiotherapy with Raster-Scanning Beam Delivery System (Ⅰ) Simulations

Corresponding author: LI Qiang,

Institute of Modern Physics,Chinese Academy of Sciences,Lanzhou 730000,China2 German Heavy-Ion Research Center GSI,Darmstadt 64291,Germany

Received Date: 2005-01-11

Accepted Date: 1900-01-01

Available Online: 2005-10-05

Abstract: Within the framework of the pilot heavy-ion therapy facility at GSI equipping an active beam delivery system of advanced raster scanning technique, the investigation of actively conformal irradiation to moving tumors using heavy ions is underway. The influences of target motion on dose homogeneity and conformity degree were theoretically studied under the condition of the active raster-scanning beam delivery system.The relationship between the target motion with different patterns and the uniformities of doses delivered by the raster scanner to different iso-energy slices of the moving target were simulated with an experimentally measured beam spill. Several strategies improving the dose homogeneity in the moving target volume were derived from these simulation results. The simulations presented in this paper provide an effective means for evaluating the dose distribution for a moving target, and the results and implications of this theoretical work establish a substantial basis for feasibility experiments of the compensation for target motion with the active raster scanner at GSI.

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Conformal Irradiation for Moving Targets in Heavy Ion Radiotherapy with Raster-Scanning Beam Delivery System (Ⅰ) Simulations

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