Characteristics of a heavy water photoneutron source in boron neutron capture therapy

Danial Salehi; Dariush Sardari; Salehi Jozani

doi:10.1088/1674-1137/37/7/078201

Chinese Physics C> 2013, Vol. 37> Issue(7) : 078201 DOI: 10.1088/1674-1137/37/7/078201

Characteristics of a heavy water photoneutron source in boron neutron capture therapy

Abstract
HTML
Reference
Related

PDF

Abstract：
Bremsstrahlung photon beams produced by medical linear accelerators are currently the most commonly used method of radiation therapy for cancerous tumors. Photons with energies greater than 8-10 MeV potentially generate neutrons through photonuclear interactions in the accelerator's treatment head, patient's body, and treatment room ambient. Electrons impinging on a heavy target generate a cascade shower of bremsstrahlung photons, the energy spectrum of which shows an end point equal to the electron beam energy. By varying the target thickness, an optimum thickness exists for which, at the given electron energy, maximum photon flux is achievable. If a source of high-energy photons i.e. bremsstrahlung, is conveniently directed to a suitable D₂O target, a novel approach for production of an acceptable flux of filterable photoneturons for boron neutron capture therapy (BNCT) application is possible. This study consists of two parts. 1. Comparison and assessment of deuterium photonuclear cross section data. 2. Evaluation of the heavy water photonuclear source.

References

[1]

Auditore L et al. Design of a Photoneutron Source Based on a 5 MeV Electron Linac Proceedings of EPAC 2004. Lucerne, Switzerland[2] Petwal V C. Pram. Jour. of Phys., 2007, 68(2): 235-241[3] Jong Kyung Kim, Kyung-O Kim. Nucl. Eng. Tech., 2009, 41(4): 531[4] Leanna R. Eller. An Investigation on Photoneutron Production from Medical Linear Accelerators (M. S. Thesis). Oregon State University, 2012 (in USA)[5] Zanini A et al. Phys. Med. Biol., 2004, 49: 571-582[6] LIU J C et al. Calculations of Photoneutrons from Varian Clinac Accelerators and Their Transmissions in Materials. Presented at Radiation Dosimetry and Safety. Taipei, 1997. SLAC-PUB-7404[7] Chilton A B, Shultis J K, Faw R. Principle of Radiation Shielding. Prentice Hall, Englewood Cliffs, New Jersey, 1984. ISBN 0-13-709907X[8] Gallmeier F X. General Purpose Photoneutron Production in MCNP4. ORNL/TM-13073. United States Department of Energy, 1995[9] Hannah E. Mitchell. An Accelerator-Based Epithermal Photoneutron Source for Boron Neutron Capture Therapy. (Ph. D. Thesis). Georgia Institute of Technology, April 1996. INEL-96/0212[10] International Atomic Energy Agency (IAEA) Handbook on Photonuclear Data for Applications Cross-Section and Spectra 1996-1999[11] Partiov F. Amm. Phys., 1964, 27: 79[12] Hamidi S, Scott M C. Nucl. Instrum. Methods in Phys. Research A, 2002, 476: 99-105[13] Reda M A, Harmon J F. A Photo neutron Source for Bulk Material Studies, Accepted to be Published in Advances in X-ray Analysis, Vol. 47, Proceedings of the 52nd Ann' Denver X-ray Conf', Denver, Colorado, 2004[14] David W. Nigg. In: Neutron Sources and Applications in Radiotherapy - A Brief History and Current Trends. 12th Int' Symp' Neu' Capt' Ther' U.S.A. Idaho. 2006

[1]	Zi-Yao Hu , Yan-Lin Ye , Jian-Ling Lou , Zai-Hong Yang , Xiao-Fei Yang , Li-Sheng Yang , Wei-Liang Pu , Kang Wei , Ying Chen , Hong-Yu Zhu , Bo-Long Xia , Jia-Xing Han , Jia-Hao Chen , Kai Ma , Dong-Xi Wang , Hao-Yu Ge , Wen-Wu Wan , Jia-Wei Bian , Ze-Yu Du , Zhe-Yang Lin , Qi-Te Li , Zhi-Huan Li , Ong-Hooi Jin , Yan-Yun Yang , Shi-Wei Xu , Jun-Bing Ma , Zhen Bai , Kang Wang , Fang-Fang Duan , He-Run Yang , Peng Ma , Xiang-Lun Wei , Tian-Li Qiu . Fragmentation of neutron-rich carbon isotopes on light targets at 27.5 MeV/nucleon. Chinese Physics C, 2026, 50(3): 1-12.
[2]	Anuj Sharma , Mukul Kumar , Raj K. Jagota , Shashi K. Dhiman . Hyperons in neutron-star cores: confronting maximum mass observational constraint of 2M_⊙. Chinese Physics C, 2026, 50(3): 1-20.
[3]	Jinneng Luo , Yiming Liu , Sichun Sun . Neutron stars and Pulsar timing arrays as Axion giant gyroscopes. Chinese Physics C, 2026, 50(2): 1-8. doi: 10.1088/1674-1137/ae1189
[4]	Hisham Anwer , A. R. Abdulghany . Alpha-decay systematics and a new scaling law in heavy and superheavy nuclei. Chinese Physics C, 2026, 50(1): 014111. doi: 10.1088/1674-1137/ae0307
[5]	Yu Jia , Jichen Pan , Jia-Yue Zhang . Soft pattern of gravitational Rutherford scattering from heavy target mass expansion. Chinese Physics C, 2026, 50(1): 013102. doi: 10.1088/1674-1137/ad62d6
[6]	Huixiao Duan , Fan Zhang , Kailei Wang , Jun Su . Nuclear temperature of spectator source extracted by neutron spectra in ¹²⁴Sn,¹⁰⁷Sn + ¹²⁰Sn collisions at 600 MeV/nucleon. Chinese Physics C, 2026, 50(1): 014110. doi: 10.1088/1674-1137/ae0f85
[7]	Chang-Lin Lan , Kuo-Zhi Xu , Yu-Ting Wei , Yang-Bo Nie , Xiao-Dong Pan , Yan-Yan Ding , Shi-Yu Zhang , Hao-Nan Li , Bo Gao , Bo Xie , Xi-Chao Ruan , Shi-Long Liu . Neutron Leakage Spectra Benchmark of Spherical Polyethylene Sample with a ²⁵²Cf fission Source. Chinese Physics C, 2026, 50(3): 1-13.
[8]	Xuesong Geng , Kaixuan Huang , Hong Shen , Lei Li , Jinniu Hu . Radial oscillations of neutron stars within density-dependent relativistic-mean field models. Chinese Physics C, 2025, 49(12): 124108. doi: 10.1088/1674-1137/adfc33
[9]	Yu. M. Gledenov , I. Chuprakov , Guohui Zhang , G. Khuukhenkhuu , M. Odsuren , B. Usukhbayar , L. Krupa , E. Sansarbayar , Jie Liu , Haofan Bai , Cong Xia , Zepeng Wu , Wenkai Ren , D. Berikov , G. Ahmadov , A. K. Bekbayev , B. Mukhametuly , E. S. Korshikov , N. T. Temerbulatova , E. B. Myrzabekova , O. Daulbayev , Y. Arynbek . Cross section measurement of the ⁶Li(n,t)⁴He reaction in the MeV neutron energy range. Chinese Physics C, 2025, 49(12): 124004. doi: 10.1088/1674-1137/ae0306
[10]	Shuo Yang , Yi-Hang Wang , Peng-Bo Zhao , Ji-Long Ma . Search for heavy vector-like B quark via pair production in fully hadronic channels at CLIC. Chinese Physics C, 2025, 49(11): 113101. doi: 10.1088/1674-1137/adf183
[11]	Zhi-Lei Ma , Zhun Lu , Hao Liu , Li Zhang . Inelastic heavy quarkonium photoproduction in p-p and Pb-Pb collisions at LHC energies. Chinese Physics C, 2025, 49(10): 103103. doi: 10.1088/1674-1137/ade1ca
[12]	Wei-Xi Kong , Ben-Wei Zhang . Fox-Wolfram moment of jet production in relativistic heavy-ion collisions. Chinese Physics C, 2025, 49(9): 094101. doi: 10.1088/1674-1137/add5d8
[13]	Yu-Xin Xiao , Qing-Fei Han , He-Xia Zhang , Han-zhong Zhang . System-size dependence of γ-jet modifications in heavy-ion collisions. Chinese Physics C, 2025, 49(12): 124101. doi: 10.1088/1674-1137/adef24
[14]	Zhen-Yu Li , Guo-Liang Yu , Zhi-Gang Wang , Jian-Zhong Gu , Hong-Tao Shen . Mass spectra of singly heavy baryons in the relativized quark model with heavy-quark dominance. Chinese Physics C, 2025, 49(11): 113107. doi: 10.1088/1674-1137/adf178
[15]	Ning Wang . Refinement of an analytical capture cross section formula. Chinese Physics C, 2025, 49(12): 124106. doi: 10.1088/1674-1137/adfe53
[16]	GUO Yan-Qing , SONG Jie . Quantitative conditions for the formation of p-wave neutron halos. Chinese Physics C, 2011, 35(2): 158-162. doi: 10.1088/1674-1137/35/2/010
[17]	YE Yan-Lin , ZHOU Xiao-Hong , LIU Wei-Ping , MA Yu-Gang , ZHANG Yu-Hu , XU Fu-Rong . Outline of the progress in the study of radioactive nuclear physics and super-heavy nuclei. Chinese Physics C, 2008, 32(S2): 1-7.
[18]	LIU Chang-Long , LU Yi-Ying , YIN LI . Effects of Additional Vacancy-Like Defects Produced by Ion Impealations on Boron Thermal Diffusion in Silicon. Chinese Physics C, 2005, 29(11): 1107-1111.
[19]	Yu Hong , Shen Qixing , Zhang Lin . Angular Distribution of Process e⁺e^－→τ⁺τ^－,τ^－→a₁υτ,a₁→ρπ and Characteristics of a₁ Meson. Chinese Physics C, 1994, 18(7): 583-590.
[20]	WU Zhong-Li . ANALYSIS OF THE MOMENTUM DISTRIBUTION WIDTH OF THE PREOJECTILE-LIKE-FRAGMENT FROM HEAVY ION COLLISIONS. Chinese Physics C, 1989, 13(8): 752-754.

Access

Get Citation

Danial Salehi, Dariush Sardari and Salehi Jozani. Characteristics of a heavy water photoneutron source in boron neutron capture therapy[J]. Chinese Physics C, 2013, 37(7): 078201. doi: 10.1088/1674-1137/37/7/078201

RIS(for EndNote,Reference Manager,ProCite)

BibTex

Txt

Milestone

Received: 2012-08-31
Revised: 1900-01-01

Article Metric

Article Views(3665)
PDF Downloads(220)
Cited by(0)

Policy on re-use

To reuse of subscription content published by CPC, the users need to request permission from CPC, unless the content was published under an Open Access license which automatically permits that type of reuse.

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Characteristics of a heavy water photoneutron source in boron neutron capture therapy

Corresponding author: Danial Salehi,

Received Date: 2012-08-31

Accepted Date: 1900-01-01

Available Online: 2013-07-05

Abstract: Bremsstrahlung photon beams produced by medical linear accelerators are currently the most commonly used method of radiation therapy for cancerous tumors. Photons with energies greater than 8-10 MeV potentially generate neutrons through photonuclear interactions in the accelerator's treatment head, patient's body, and treatment room ambient. Electrons impinging on a heavy target generate a cascade shower of bremsstrahlung photons, the energy spectrum of which shows an end point equal to the electron beam energy. By varying the target thickness, an optimum thickness exists for which, at the given electron energy, maximum photon flux is achievable. If a source of high-energy photons i.e. bremsstrahlung, is conveniently directed to a suitable D₂O target, a novel approach for production of an acceptable flux of filterable photoneturons for boron neutron capture therapy (BNCT) application is possible. This study consists of two parts. 1. Comparison and assessment of deuterium photonuclear cross section data. 2. Evaluation of the heavy water photonuclear source.

HTML

Reference (1)

Characteristics of a heavy water photoneutron source in boron neutron capture therapy

Abstract：

References

Access

Article Metrics

Metrics

通讯作者: 陈斌, bchen63@163.com

Email This Article