Neutron beam optimization based on a 7Li(p,n)7Be reaction for treatment of deep-seated brain tumors by BNCT

Zahra Ahmadi Ganjeh; S. Farhad Masoudi

doi:10.1088/1674-1137/38/10/108203

Chinese Physics C> 2014, Vol. 38> Issue(10) : 108203 DOI: 10.1088/1674-1137/38/10/108203

Neutron beam optimization based on a ⁷Li(p,n)⁷Be reaction for treatment of deep-seated brain tumors by BNCT

Zahra Ahmadi Ganjeh ,
S. Farhad Masoudi ^,

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Abstract：
Neutron beam optimization for accelerator-based Boron Neutron Capture Therapy (BNCT) is investigated using a ⁷Li(p,n)⁷Be reaction. Design and optimization have been carried out for the target, cooling system, moderator, filter, reflector, and collimator to achieve a high flux of epithermal neutron and satisfy the IAEA criteria. Also, the performance of the designed beam in tissue is assessed by using a simulated Snyder head phantom. The results show that the optimization of the collimator and reflector is critical to finding the best neutron beam based on the ⁷Li(p,n)⁷Be reaction. Our designed beam has 2.49×10⁹n/cm²s epithermal neutron flux and is suitable for BNCT of deep-seated brain tumors.

References

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Zahra Ahmadi Ganjeh and S. Farhad Masoudi. Neutron beam optimization based on a ⁷Li(p,n)⁷Be reaction for treatment of deep-seated brain tumors by BNCT[J]. Chinese Physics C, 2014, 38(10): 108203. doi: 10.1088/1674-1137/38/10/108203

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Received: 2013-11-04
Revised: 1900-01-01

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沈阳化工大学材料科学与工程学院沈阳 110142

Neutron beam optimization based on a ⁷Li(p,n)⁷Be reaction for treatment of deep-seated brain tumors by BNCT

Zahra Ahmadi Ganjeh
S. Farhad Masoudi ^,

Corresponding author: S. Farhad Masoudi,

Received Date: 2013-11-04
Accepted Date: 1900-01-01
Available Online: 2014-10-05

Abstract: Neutron beam optimization for accelerator-based Boron Neutron Capture Therapy (BNCT) is investigated using a ⁷Li(p,n)⁷Be reaction. Design and optimization have been carried out for the target, cooling system, moderator, filter, reflector, and collimator to achieve a high flux of epithermal neutron and satisfy the IAEA criteria. Also, the performance of the designed beam in tissue is assessed by using a simulated Snyder head phantom. The results show that the optimization of the collimator and reflector is critical to finding the best neutron beam based on the ⁷Li(p,n)⁷Be reaction. Our designed beam has 2.49×10⁹n/cm²s epithermal neutron flux and is suitable for BNCT of deep-seated brain tumors.