Neutron beam optimization based on a 7Li(p,n)7Be reaction for treatment of deep-seated brain tumors by BNCT

Zahra Ahmadi Ganjeh; S. Farhad Masoudi

doi:10.1088/1674-1137/38/10/108203

Chinese Physics C> 2014, Vol. 38> Issue(10) : 108203 DOI: 10.1088/1674-1137/38/10/108203

Neutron beam optimization based on a ⁷Li(p,n)⁷Be reaction for treatment of deep-seated brain tumors by BNCT

Zahra Ahmadi Ganjeh ,
S. Farhad Masoudi ^,

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Abstract：
Neutron beam optimization for accelerator-based Boron Neutron Capture Therapy (BNCT) is investigated using a ⁷Li(p,n)⁷Be reaction. Design and optimization have been carried out for the target, cooling system, moderator, filter, reflector, and collimator to achieve a high flux of epithermal neutron and satisfy the IAEA criteria. Also, the performance of the designed beam in tissue is assessed by using a simulated Snyder head phantom. The results show that the optimization of the collimator and reflector is critical to finding the best neutron beam based on the ⁷Li(p,n)⁷Be reaction. Our designed beam has 2.49×10⁹n/cm²s epithermal neutron flux and is suitable for BNCT of deep-seated brain tumors.

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[1]

Bleuel D L, Donahue R J, Ludewigt B A, Vujic J. Med. Phys., 1998, 25: 1725-1734[2] Sakamoto S, Kiger W S, Harling O K. Med. Phys., 1999, 26: 1979-1998[3] Lee C L, ZHOU X L. Methods Phys. Res. B, 1999, 152: 1-11[4] Montagnini B, Cerullo N, Esposito J, Giustia V et al. Phys. Res. A, 2002, 476: 90-98[5] Blue T E, Yanch J C. J. Neuro-Onco., 2003, 62: 19-31[6] Burlon A A, Kreiner A J. Nucl. Instrum. Methods Phys. Res. B, 2008, 266: 763-771[7] Salehi D, Sardari D, Salehi Jozani M. Chinese Phys. C, 2013, 37: 078201[8] CHENG D W, LU J B, YANG D et al. Chinese Phys. C, 2012, 36: 905[9] IAEA-TECDOC-1223, 2001, International Atomic Energy Agency, 2001[10] Randers G, Brenner D J, Med. Phys., 1998, 25: 894-896[11] Bayanov B, Belov V, Kindyuk V et al. Appl. Radiat. Isot., 2004, 61: 817-821[12] KIM J K, KIM K O. Nucl. Eng. Technol., 2009, 41: 531-544[13] Tanaka K, Yokobori H, Kobayashi E et al. Appl. Radiat. Isot., 2009, 67: 259-265[14] Incropera F P, DeWitt P D. Introduction to Heat Transfer. 4th ed. Published: New York: Wiley, 2002[15] Rasouli F S, Masoudi S F, Kasesaz Y. Ann. Nucl. Energy., 2012, 39: 18-25[16] Rahmani F, Shahriari M. Ann. Nucl. Energy, 2011, 38: 404-409[17] Durisi E, Zanini A, Manfredotti C et al. Nucl. Instrum. Methods Phys. Res. A, 2007, 574: 363-369[18] Herrera M S, Gonzalez S J, Minsky D M et al. Phys. Med., 2013, 29: 436-449

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[18]	Li Yangguo . Antiproton -Nucleus Charge Exchange Reaction and Inelastic Scattering. Chinese Physics C, 1996, 20(11): 1021-1027.
[19]	ZHU Xiang , SHEN Wen-Qing , HU Xiao-Qing , ZHU Yong-Tai , WANG Bing . A SIMPLE MODEL ANALYSIS OF THE INCOMPLETE DIC REACTION. Chinese Physics C, 1990, 14(9): 835-841.
[20]	WANG Man , LI Jin , CUI Xiang-Zong , XIA Xiao-Mi , LAI Yuan-Fen , YAO Xiao-Guang . PROTOTYPE OF END CAP SHOWER COUNTERAND ITS BEAM TEST. Chinese Physics C, 1987, 11(3): 321-326.

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Zahra Ahmadi Ganjeh and S. Farhad Masoudi. Neutron beam optimization based on a ⁷Li(p,n)⁷Be reaction for treatment of deep-seated brain tumors by BNCT[J]. Chinese Physics C, 2014, 38(10): 108203. doi: 10.1088/1674-1137/38/10/108203

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Received: 2013-11-04
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

Neutron beam optimization based on a ⁷Li(p,n)⁷Be reaction for treatment of deep-seated brain tumors by BNCT

Corresponding author: S. Farhad Masoudi,

Received Date: 2013-11-04

Accepted Date: 1900-01-01

Available Online: 2014-10-05

Abstract: Neutron beam optimization for accelerator-based Boron Neutron Capture Therapy (BNCT) is investigated using a ⁷Li(p,n)⁷Be reaction. Design and optimization have been carried out for the target, cooling system, moderator, filter, reflector, and collimator to achieve a high flux of epithermal neutron and satisfy the IAEA criteria. Also, the performance of the designed beam in tissue is assessed by using a simulated Snyder head phantom. The results show that the optimization of the collimator and reflector is critical to finding the best neutron beam based on the ⁷Li(p,n)⁷Be reaction. Our designed beam has 2.49×10⁹n/cm²s epithermal neutron flux and is suitable for BNCT of deep-seated brain tumors.

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Neutron beam optimization based on a ⁷Li(p,n)⁷Be reaction for treatment of deep-seated brain tumors by BNCT

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Neutron beam optimization based on a ⁷Li(p,n)⁷Be reaction for treatment of deep-seated brain tumors by BNCT

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