Spot-scanning beam delivery with laterally-and longitudinally-mixed spot size pencil beams in heavy ion radiotherapy

Yuan-Lin Yan; Xin-Guo Liu; Zhong-Ying Dai; Yuan-Yuan Ma; Peng-Bo He; Guo-Sheng Shen; Teng-Fei Ji; Hui Zhang; Qiang Li

doi:10.1088/1674-1137/41/9/098201

Chinese Physics C> 2017, Vol. 41> Issue(9) : 098201 DOI: 10.1088/1674-1137/41/9/098201

Spot-scanning beam delivery with laterally-and longitudinally-mixed spot size pencil beams in heavy ion radiotherapy

Yuan-Lin Yan ^1,2,3,4 ,
Xin-Guo Liu ^1,2,3 ,
Zhong-Ying Dai ^1,2,3 ,
Yuan-Yuan Ma ^1,2,3,4 ,
Peng-Bo He ^1,2,3 ,
Guo-Sheng Shen ^1,2,3,4 ,
Teng-Fei Ji ^1,2,3,4 ,
Hui Zhang ^1,2,3,4 ,
Qiang Li ^1,2,3,,

1.
Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China
2.
Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou 730000, China
3.
Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine, Gansu Province, Lanzhou 730000, China
4.
University of Chinese Academy of Sciences, Beijing 100049, China

Abstract
HTML
Reference
Related

PDF

Abstract：
The three-dimensional (3D) spot-scanning method is one of the most commonly used irradiation methods in charged particle beam radiotherapy. Generally, spot-scanning beam delivery utilizes the same size pencil beam to irradiate the tumor targets. Here we propose a spot-scanning beam delivery method with laterally-and longitudinally-mixed size pencil beams for heavy ion radiotherapy. This uses pencil beams with a bigger spot size in the lateral direction and wider mini spread-out Bragg peak (mini-SOBP) to irradiate the inner part of a target volume, and pencil beams with a smaller spot size in the lateral direction and narrower mini-SOBP to irradiate the peripheral part of the target volume. Instead of being controlled by the accelerator, the lateral size of the pencil beam was adjusted by inserting Ta scatterers in the beam delivery line. The longitudinal size of the pencil beam (i.e. the width of the mini-SOBP) was adjusted by tilting mini ridge filters along the beam direction. The new spot-scanning beam delivery using carbon ions was investigated theoretically and compared with traditional spot-scanning beam delivery. Our results show that the new spot-scanning beam delivery has smaller lateral penumbra, steeper distal dose fall-off and the dose homogeneity (1-standard deviation/mean) in the target volume is better than 95%.
- heavy ion radiotherapy ,
- spot-scanning ,
- beam spot size ,
- mini spread-out Bragg peak (mini-SOBP) ,
- mini ridge filter (mini-RF)

References

[1]	T. Kanai, K. Kawachi, Y. Kumamoto et al, Med. Phys., 7(4):365-369(1980)
[2]	T. Haberer, W. Becher, and D. Schardt, Nucl. Instrum. Methods Phys. Res. Sect. A, 330(1-2):296-305(1993)
[3]	J. H. Kang, J. J. Wilkens, and U. Oelfke, Med. Phys., 34(9):3457-3464(2007)
[4]	H. Tsujii, T. Kamada, T. Shirai et al, Carbon-Ion Radiotherapy (Germany:Springer, 2014), p.58-60
[5]	Q. Li, X. G. Liu, Z. Y. Dai et al, edited by W. Liu et al, American Institute of Physics Conference Series (AIP Publishing, 2013), p.174-178
[6]	Z. Y. Dai, Q. Li, and X. G. Liu, Chin. Phys. C, 36(8):784-791(2012)
[7]	T. Inaniwa, T. Furukawa, and T. Tomitani, Med. Phys., 34(8):3302-3311(2007)
[8]	T. Furukawa, K. Noda, Nucl. Instrum. Methods Phys. Res. Sect. A, 489(1-3):59-67(2002)
[9]	T. Furukawa, K. Noda, E. Urakabe, Nucl. Instrum. Methods Phys. Res. Sect. A, 503(3):485-495(2003)
[10]	J. H. Kang, Optimization of Scanning Parameters in Intensity Modulated Proton Therapy, Ph.D.Thesis (Germany:the Ruperto-Carola University of Heidelberg, 2008)
[11]	S. Fujitaka, T. Takayanagi, and R. Fujimoto, Phys. Med. Biol., 54(10):3101-3111(2009)
[12]	T. Nakagawa, K. Yoda, Med. Phys., 27(4):712-715(2000)
[13]	J. C. Yang, J. Shi, and W. P. Chai, Nucl. Instrum. Methods Phys. Res. Sect. A, 756:19-22(2014)
[14]	J. Shi, J. C. Yang, J. W. Xia et al, Nucl. Instrum. Methods Phys. Res. Sect. A, 714:105-109(2013)
[15]	N. Bassler, Armin Luhr, D. C. Hansen et al, SHIELD-HIT12A-User's Guide (2016)
[16]	N. Bassler, D. C. Hansen, A. Luhr et al, Journal of Physics:Conference Series (IOP Publishing, 2014), 012004
[17]	D. C. Hansen, A. Luhr, and R. Herrmann, International Journal of Radiation Biology, 88(1-2):195-199(2012)
[18]	Y. L. Yan, X. G. Liu et al, Nuclear Physics Review, 33(1):105-111(2016)(in chinese)
[19]	M. Torikoshi, S. Minohara, N. Kanematsu et al, Journal of Radiation Research, 48(Suppl A):A15-A25(2007)
[20]	T. Himukai, T. Furukawa, and E. Takeshita, Nucl. Instrum. Methods Phys. Res. Sect. B, 269(24):2891-2894(2011)
[21]	B. Schaffner, T. Kanai, and Y. Futami, Med. Phys., 27(4):716-724(2000)
[22]	U. Weber, G. Kraft, Phys. Med. Biol., 44(11):2765-2775(1999)
[23]	M. Kramer, O. Jakel, and T. Haberer, Phys. Med. Biol. Printed in the UK, 45(11):3299-3317(2000)
[24]	A. Lomax, Phys. Med. Biol., 44(1):185-205(1999)
[25]	M. H Phillips, E. Pedroni, H. Blattmann et al, Phys. Med. Bid. Printed in the UK, 37(1):223-234(1992)
[26]	Christoph Bert, Sven O Grozinger, and Eike Rietzel, Phys. Med. Biol., 53(9):2253-2265(2008)

[1]	Yi Wang , Qin Li , Nan Chen , Jin-Ming Cheng , Cheng-Gang Li , Hong Li , Quan-Hong Long , Jin-Shui Shi , Jian-Jun Deng . Experimental comparison of various techniques for spot size measurement of high-energy X-ray sources. Chinese Physics C, 2016, 40(8): 086205. doi: 10.1088/1674-1137/40/8/086205
[2]	Yi Wang , Qin Li , Nan Chen , Jin-Ming Cheng , Yu-Tong Xie , Yun-Long Liu , Quan-Hong Long . Spot size measurement of a flash-radiography source using the pinhole imaging method. Chinese Physics C, 2016, 40(7): 076202. doi: 10.1088/1674-1137/40/7/076202
[3]	Yun Zheng , Xiao-Guang Wu , Guang-Sheng Li , Cong-Bo Li , Chuang-Ye He , Qi-Ming Chen , Jian Zhong , Wen-Kui Zhou , Li-Tao Deng , Bao-Ji Zhu . Mini-orange spectrometer at CIAE. Chinese Physics C, 2016, 40(8): 086002. doi: 10.1088/1674-1137/40/8/086002
[4]	PANG Cheng-Guo , SU You-Wu , WANG Wen-Jun , LUO Xiao-Ming , XU Jun-Ku , LI Wu-Yuan , YUAN Jiao , YAO Ze-En . Monte Carlo simulation of carbon ion radiotherapy for the human eye. Chinese Physics C, 2015, 39(1): 018201. doi: 10.1088/1674-1137/39/1/018201
[5]	YANG Min , WANG Xiao-Long , LIU Yi-Peng , MENG Fan-Yong , LI Xing-Dong , LIU Wen-Li , WEI Dong-Bo . Automatic calibration method of voxel size for cone-beam 3D-CT scanning system. Chinese Physics C, 2014, 38(4): 046202. doi: 10.1088/1674-1137/38/4/046202
[6]	LI Hai-Bo , ZHU Shi-Hai . Mini-review of rare charmonium decays at BESⅢ. Chinese Physics C, 2012, 36(10): 932-940. doi: 10.1088/1674-1137/36/10/003
[7]	ZHANG Ai-Wu , YU Bo-Xiang , XIE Yu-Guang , LIU Hong-Bang , AN Zheng-Hua , WANG Zhi-Gang , CAI Xiao , SUN Xi-Lei , SHI Feng , FANG Jian , XUE Zhen , SUN Li-Jun , GE Yong-Shuai , LIU Ying-Biao , HU Tao , ZHOU Li , , . Experimental study of a THGEM detector with mini-rims. Chinese Physics C, 2012, 36(2): 142-145. doi: 10.1088/1674-1137/36/2/007
[8]	DAI Zhong-Ying , LI Qiang , LIU Xin-Guo , JIN Xiao-Dong , HUANG Qi-Yan , XIAO Guo-Qing . Active spot-scanning test with heavy ions at HIRFL-CSR. Chinese Physics C, 2012, 36(8): 784-791. doi: 10.1088/1674-1137/36/8/018
[9]	WANG Yang-Yang , ZHAO Lin-Jie , YUAN Zhong-Sheng , ZHANG Dan-Dan , FANG Wei , XU Ming-Mei . System size in relativistic heavy ion collisions. Chinese Physics C, 2011, 35(3): 264-268. doi: 10.1088/1674-1137/35/3/010
[10]	LI De-Sheng , TIAN Feng-Ge , CHEN Gang . Study on the method of mini-jet identification in relativistic heavy ion collisions. Chinese Physics C, 2011, 35(9): 833-837. doi: 10.1088/1674-1137/35/9/009
[11]	SHAN Lian-Qiang , WU Feng-Juan , GUAN Hui-Jun , ZHANG Jing-Bo , TANG Gui-Xin , HUO Lei . Size of the freeze-out source in high energy heavy ion collisions. Chinese Physics C, 2009, 33(5): 359-363. doi: 10.1088/1674-1137/33/5/008
[12]	LI Cheng-Gang , LI Qin , SHI Jin-Shui , DENG Jian-Jun . Spot size diagnostics for flash radiographic X-ray sources at LAPA. Chinese Physics C, 2009, 33(S2): 157-160. doi: 10.1088/1674-1137/33/S2/041
[13]	ZHOU Qing-Ming , ZHANG Hong , LI Qiang , WEI Li-Li , LIU Xin-Guo , GU Meng-Xia , WU Gui-Hong , DAI Zhong-Yin . Rotating wheel filter design and optimization for a uniform depth dose distribution in heavy ion therapy. Chinese Physics C, 2008, 32(S2): 294-298.
[14]	LI Qiang . Conformal Irradiation to Moving Targets in Heavy Ion Radiotherapy with Raster-Scanning Beam Delivery System: (II) Feasibility Experiments. Chinese Physics C, 2006, 30(9): 925-929.
[15]	QIAN Hai-Jie , YAN Yong-Lian , SU Run , WANG Jia-Ou . Study on Beam Spot Size Requirement in PES, BSRF and the Beamline Upgrade. Chinese Physics C, 2005, 29(S1): 144-147.
[16]	LI Qiang . Conformal Irradiation for Moving Targets in Heavy Ion Radiotherapy with Raster-Scanning Beam Delivery System (Ⅰ) Simulations. Chinese Physics C, 2005, 29(10): 1006-1011.
[17]	WANG Sheng , FANG Shou-Xian , ZHANG Chuang . Beam-Beam Study in Beijing Electron Positron Collider mini-β Scheme. Chinese Physics C, 2001, 25(8): 780-786.
[18]	Li Qiang , Wei Zengquan , Li Wenjian , Zhou Guangming , Dang Bingrong , Cai Xichen , He Jing , Xie Hongmei , Han Guangwu , Huang Tao , Chen Weiqiang , Wang Jufang , Zhang Shumin . Extending of the Bragg Peak of Heavy lon Beam. Chinese Physics C, 1998, 22(7): 646-650.
[19]	Li Qiang , Wei Zengquan , Dang Bingrong , Li Wenjian . Investigation and Application of Heavy lon Bragg Peak. Chinese Physics C, 1997, 21(6): 571-575.
[20]	Tang Esheng , Cui Mingqi , Liu Libing , Xu Wenxuan , Chao Zhiyu , Wu Yingrong , Wang Chunxi , Xian Dingchang . Preliminary Observation of the Synchrotron Radiation Spot From Wiggler Beam Line 4W1A at IHEP. Chinese Physics C, 1990, 14(S3): 231-236.

Access

Get Citation

Yuan-Lin Yan, Xin-Guo Liu, Zhong-Ying Dai, Yuan-Yuan Ma, Peng-Bo He, Guo-Sheng Shen, Teng-Fei Ji, Hui Zhang and Qiang Li. Spot-scanning beam delivery with laterally-and longitudinally-mixed spot size pencil beams in heavy ion radiotherapy[J]. Chinese Physics C, 2017, 41(9): 098201. doi: 10.1088/1674-1137/41/9/098201

RIS(for EndNote,Reference Manager,ProCite)

BibTex

Txt

Milestone

Received: 2016-08-10
Revised: 2017-04-23

Fund

Supported by Key Project of National Natural Science Foundation of China (U1232207), National Key Technology Support Program of the Ministry of Science and Technology of China (2015BAI01B11), National Key Research and Development Program of the Ministry of Science and Technology of China (2016YFC0904602) and National Natural Science Foundation of China (11075191, 11205217, 11475231, 11505249)

Article Metric

Article Views(1656)
PDF Downloads(48)
Cited by(0)

Policy on re-use

To reuse of subscription content published by CPC, the users need to request permission from CPC, unless the content was published under an Open Access license which automatically permits that type of reuse.

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Spot-scanning beam delivery with laterally-and longitudinally-mixed spot size pencil beams in heavy ion radiotherapy

Abstract：

References

Access

Article Metrics

Metrics

通讯作者: 陈斌, bchen63@163.com

Email This Article

Spot-scanning beam delivery with laterally-and longitudinally-mixed spot size pencil beams in heavy ion radiotherapy

Corresponding author: Qiang Li,

HTML

目录