Zinc and ZnT3 mRNA Expression in Mouse Brain by SRXRF

ZHANG Yuan-Xun; WANG Ying-Song; LI De-Lu; ZHANG Gui-Lin; HUANG Yu-Ying; HE Wei; LONG Jian-Gang; SHEN Hui

Chinese Physics C> 2005, Vol. 29> Issue(S1) : 68-70

Zinc and ZnT3 mRNA Expression in Mouse Brain by SRXRF

Shanghai Institute of Applied Physics, CAS, Shanghai 201800, China2 Institute of High Energy Physics, CAS, Beijing 100049, China3 Department of Military Hygiene, Second Military Medical University, Shanghai 200433, China

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Abstract：
In order to explore the interaction and function between the ZnT3 mRNA expression and zinc elemental distribution in brain slice of mouse, zinc concentration and its distribution were determined by SRXRF and ZnT3 mRNA expression in tissue was examined by RT-PCR method. The results show that the zinc content in cerebral cortex and hippocampus was significantly higher than in other positions. The highest expression of ZnT3 mRNA was observed in cerebrum, hippocampus and testis. However, the ZnT3 mRNA was not detected in heart, liver, lung, spleen, kidney, intestine, olfactory bulb and cerebellum. Furthermore, the results suggest that ZnT3 facilitates the accumulation of zinc in synaptic vesicles and may play important roles in structuring of vesicular zinc pool.

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ZHANG Yuan-Xun, WANG Ying-Song, LI De-Lu, ZHANG Gui-Lin, HUANG Yu-Ying, HE Wei, LONG Jian-Gang and SHEN Hui. Zinc and ZnT3 mRNA Expression in Mouse Brain by SRXRF[J]. Chinese Physics C, 2005, 29(S1): 68-70.

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Received: 2005-10-28
Revised: 1900-01-01

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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

Zinc and ZnT3 mRNA Expression in Mouse Brain by SRXRF

Corresponding author: ZHANG Yuan-Xun,

Shanghai Institute of Applied Physics, CAS, Shanghai 201800, China2 Institute of High Energy Physics, CAS, Beijing 100049, China3 Department of Military Hygiene, Second Military Medical University, Shanghai 200433, China

Received Date: 2005-10-28

Accepted Date: 1900-01-01

Available Online: 2005-01-02

Abstract: In order to explore the interaction and function between the ZnT3 mRNA expression and zinc elemental distribution in brain slice of mouse, zinc concentration and its distribution were determined by SRXRF and ZnT3 mRNA expression in tissue was examined by RT-PCR method. The results show that the zinc content in cerebral cortex and hippocampus was significantly higher than in other positions. The highest expression of ZnT3 mRNA was observed in cerebrum, hippocampus and testis. However, the ZnT3 mRNA was not detected in heart, liver, lung, spleen, kidney, intestine, olfactory bulb and cerebellum. Furthermore, the results suggest that ZnT3 facilitates the accumulation of zinc in synaptic vesicles and may play important roles in structuring of vesicular zinc pool.

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Zinc and ZnT3 mRNA Expression in Mouse Brain by SRXRF

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