Small-angle X-ray scattering probe of intermolecularinteraction in red blood cells

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LIU Guan-Fen, WANG We-Jia, XU Jia-Hua and DONG Yu-Hui. Small-angle X-ray scattering probe of intermolecularinteraction in red blood cells[J]. Chinese Physics C, 2015, 39(3): 038001. doi: 10.1088/1674-1137/39/3/038001
LIU Guan-Fen, WANG We-Jia, XU Jia-Hua and DONG Yu-Hui. Small-angle X-ray scattering probe of intermolecularinteraction in red blood cells[J]. Chinese Physics C, 2015, 39(3): 038001.  doi: 10.1088/1674-1137/39/3/038001 shu
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Received: 2014-04-07
Revised: 2014-08-12
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Small-angle X-ray scattering probe of intermolecularinteraction in red blood cells

    Corresponding author: DONG Yu-Hui,

Abstract: With high concentrations of hemoglobin (Hb) in red blood cells, self-interactions among these molecules could increase the propensities of their polymerization and aggregation. In the present work, high concentration Hb in solution and red blood cells were analyzed by small-angle X-ray scattering. Calculation of the effective structure factor indicates that the interaction of Hb molecules is the same when they are crowded together in both the cell and physiological saline. The Hb molecules stay individual without the formation of aggregates and clusters in cells.

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