Fast and accurate generation method of PSF-based system matrix for PET reconstruction

  • This work investigates the positional single photon incidence response (P-SPIR) to provide an accurate point spread function (PSF)-contained system matrix and its incorporation within the image reconstruction framework. Based on the Geant4 Application for Emission Tomography (GATE) simulation, P-SPIR theory takes both incidence angle and incidence position of the gamma photon into account during crystal subdivision, instead of only taking the former into account, as in single photon incidence response (SPIR). The response distribution obtained in this fashion was validated using Monte Carlo simulations. In addition, two-block penetration and normalization of the response probability are introduced to improve the accuracy of the PSF. With the incorporation of the PSF, the homogenization model is then analyzed to calculate the spread distribution of each line-of-response (LOR). A primate PET scanner, Eplus-260, developed by the Institute of High Energy Physics, Chinese Academy of Sciences (IHEP), was employed to evaluate the proposed method. The reconstructed images indicate that the P-SPIR method can effectively mitigate the depth-of-interaction (DOI) effect, especially at the peripheral area of field-of-view (FOV). Furthermore, the method can be applied to PET scanners with any other structures and list-mode data format with high flexibility and efficiency.
      PCAS:
  • 加载中
  • [1] B. Karuta and R. Lecomte, IEEE Trans. Med. Imaging, 11(3):379-385 (1992)
    [2] V. Andrea, S. Nils, E. Lars et al, Eur. J. Nucl. Med. Mol. Imaging, 36(10):1639-1650 (2009)
    [3] J. Thies, Z. Vilia, S. Jessica et al, Eur. J. Nucl. Med. Mol. Imaging, 3(1):1-17 (2016)
    [4] T. Thonnapong, I. Yoko, S. Takahiro et al, Radiological Physics and Technology, 9(1):127-137 (2016)
    [5] K. Kazuya, K. Kenichi, T. Makiko et al, British journal of radiology, 89(1063):20150938 (2016)
    [6] V. Astakhov, P. Gumplinger, C. Moisan et al, IEEE Transactions on Nuclear Science, 50(5):1373-1378 (2003)
    [7] S. Salvador, D. Huss, D. Brasse et al, IEEE Transactions on Nuclear Science, 56(1):17-23 (2009)
    [8] M. Ito, J. S. Lee, S. I. Kwon et al, IEEE Transactions on Nuclear Science, 57(3):976-981 (2010)
    [9] V. Y. Panin, F. Kehren, H. Rothfuss et al, IEEE Transactions on Nuclear Science, 53(1):152-159 (2006)
    [10] S. Tong, A. M. Alessio and P. E. Kinahan. Phys. Med. Biol, 55(5):1453-1473 (2010)
    [11] K. Lee, P. E. Kinahan, J. A. Fessler et al, Phys. Med. Biol, 49(19):4563-4578 (2004)
    [12] K. Saha, K. J. Straus, Y. Chen et al, J. Appl. Phys, 116(8) (2014)
    [13] J. Qi, R. M. Leahy, S. R. Cherry et al, Phys. Med. Biol, 43(4):1001-1013 (1998)
    [14] R. T. Yao, R. M. Ramachandra, N. Mahajan et al, Phys. Med. Biol, 57(21):6827-6848 (2012)
    [15] A. Lougovski, F. Hofheinz, J. Maus et al, Phys. Med. Biol, 59(3):561-577 (2014)
    [16] X. Fan, H. P. Wang, M. K. Yun et al, Chin. Phys. B, 24(1):500-542 (2015)
    [17] K. Assi, V. Breton, I. Buvat et al, Nucl. Instrum. Methods Phys. Res., Sect. A, 527(1):180-189 (2004)
    [18] M. Caadas, P. Arce, M. P. Rato, Phys. Med. Biol, 56(1):273-288 (2011)
    [19] National Electrical Manufacturers Association (NEMA), NEMA Standards Publication NU 4-2008:Performance Measurement for Small Animal Positron Emission Tomographs (Washington, DC:NEMA, 2008)
    [20] I. J. Ahn, J. H. Kim, Y. J. Chang et al, IEEE Transactions on Nuclear Science, 62(3):859-868 (2015)
    [21] M. Rafecas, B. Mosler, M. Dietz et al, IEEE Transactions on Nuclear Science, 51(5):2597-2605 (2004)
    [22] F. R. Rannou, A. F. Chatziioannou, IEEE Symposium Conference Record Nuclear Science 2004, 6:3433-3436 (2004)
    [23] J. D. Leroux, C. Thibaudeau, R. Lecomte and R. Fontaine, 2007 IEEE Nuclear Science Symposium Conference Record, 5:3644-3648 (2007)
    [24] F. Boisson, C. J. Wimberley, W. Lehnert et al, Phys. Med. Biol, 58(19):6749-6763 (2013)
    [25] L. Y. Wang, J. Zhu, X. Liang et al, Phys. Med. Biol, 60(1):137-150 (2015)
    [26] J. Zhou and J. Y. Qi, Phys. Med. Biol, 56(20):6739-6757 (2011)
    [27] M. Aykac, V. Y. Panin, I. Hong and M. E. Casey. 2014 IEEE Nuclear Science Symposium and Medical Imaging Conference, 1-5 (2014)
  • 加载中

Get Citation
null. Fast and accurate generation method of PSF-based system matrix for PET reconstruction[J]. Chinese Physics C, 2017, 41(4): 048201. doi: 10.1088/1674-1137/41/4/048201
null. Fast and accurate generation method of PSF-based system matrix for PET reconstruction[J]. Chinese Physics C, 2017, 41(4): 048201.  doi: 10.1088/1674-1137/41/4/048201 shu
Milestone
Received: 2016-08-20
Fund

    null

Article Metric

Article Views(72)
PDF Downloads(63)
Cited by(0)
Policy on re-use
To reuse of subscription content published by CPC, the users need to request permission from CPC, unless the content was published under an Open Access license which automatically permits that type of reuse.
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Email This Article

Title:
Email:

Fast and accurate generation method of PSF-based system matrix for PET reconstruction

Fund Project:  null

Abstract: This work investigates the positional single photon incidence response (P-SPIR) to provide an accurate point spread function (PSF)-contained system matrix and its incorporation within the image reconstruction framework. Based on the Geant4 Application for Emission Tomography (GATE) simulation, P-SPIR theory takes both incidence angle and incidence position of the gamma photon into account during crystal subdivision, instead of only taking the former into account, as in single photon incidence response (SPIR). The response distribution obtained in this fashion was validated using Monte Carlo simulations. In addition, two-block penetration and normalization of the response probability are introduced to improve the accuracy of the PSF. With the incorporation of the PSF, the homogenization model is then analyzed to calculate the spread distribution of each line-of-response (LOR). A primate PET scanner, Eplus-260, developed by the Institute of High Energy Physics, Chinese Academy of Sciences (IHEP), was employed to evaluate the proposed method. The reconstructed images indicate that the P-SPIR method can effectively mitigate the depth-of-interaction (DOI) effect, especially at the peripheral area of field-of-view (FOV). Furthermore, the method can be applied to PET scanners with any other structures and list-mode data format with high flexibility and efficiency.

    HTML

Reference (27)

目录

/

DownLoad:  Full-Size Img  PowerPoint
Return
Return